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Science 4 August 2006:
Vol. 313. no. 5787, pp. 627 - 628
DOI: 10.1126/science.1131712
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Perspectives

IMMUNOLOGY:
Enhanced: Sugar Determines Antibody Activity

Dennis R. Burton1 and Raymond A. Dwek2

Understanding the functional consequences of the identity and sequence of the sugars attached to antibodies may be useful in designing therapies for a range of disorders.

1D. R. Burton is in the Departments of Immunology and Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. E-mail: burton{at}scripps.edu

2R. A. Dwek is at the Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. E-mail: raymond.dwek{at}exeter.ox.ac.uk

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