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Science 28 July 2006:
Vol. 313. no. 5786, pp. 447 - 448
DOI: 10.1126/science.1131205
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Perspectives

MOLECULAR BIOLOGY:
Self-Correcting Messages

Patrick Cramer

Mistakes can occur as RNA polymerase copies DNA into transcripts. A proofreading mechanism that removes the incorrect RNA is triggered by the erroneous RNA itself.

The author is at the Gene Center Munich, Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. E-mail: cramer{at}lmb.uni-muenchen.de

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nonrandom variations in human cancer ESTs indicate that mRNA heterogeneity increases during carcinogenesis.
M. Brulliard, D. Lorphelin, O. Collignon, W. Lorphelin, B. Thouvenot, E. Gothie, S. Jacquenet, V. Ogier, O. Roitel, J.-M. Monnez, et al. (2007)
PNAS 104, 7522-7527
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