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Acetyl-CoA carboxylase controls fat storage and utilization in adipose cells. An important regulator of this enzyme modulates its degradation and is a potential therapeutic target for treatment of insulin resistance and obesity.
The authors are in the Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0673, USA. E-mail: jolefsky{at}ucsd.edu
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RESEARCH ARTICLES
Ling Qi, Jose E. Heredia, Judith Y. Altarejos, Robert Screaton, Naomi Goebel, Sherry Niessen, Ian X. MacLeod, Chong Wee Liew, Rohit N. Kulkarni, James Bain, Christopher Newgard, Michael Nelson, Ronald M. Evans, John Yates, and Marc Montminy (23 June 2006) Science312 (5781), 1763.
[DOI: 10.1126/science.1123374] |Abstract »|Full Text »|PDF »|Supporting Online Material »
