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Science 16 June 2006:
Vol. 312. no. 5780, pp. 1606 - 1608
DOI: 10.1126/science.1129797

Perspectives

IMMUNOLOGY:
Discriminating Microbe from Self Suffers a Double Toll

Christopher C. Goodnow

The autoimmune disease lupus is caused by immune cells that secrete antibodies to the patient's own antigens. A mouse version of the disease reveals two genes that lead to this disregulation.


The author is in the John Curtin School of Medical Research and Australian Phenomics Facility, The Australian National University, Post Office Box 334, Canberra, ACT 0200, Australia. E-mail: chris.goodnow{at}anu.edu.au

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Taxol Increases the Amount and T Cell Activating Ability of Self-Immune Stimulatory Multimolecular Complexes Found in Ovarian Cancer Cells.
N. Tsuda, D. Z. Chang, T. Mine, C. Efferson, A. Garcia-Sastre, X. Wang, S. Ferrone, and C. G. Ioannides (2007)
Cancer Res. 67, 8378-8387
   Abstract »    Full Text »    PDF »
BAFF and MyD88 signals promote a lupuslike disease independent of T cells.
J. R. Groom, C. A. Fletcher, S. N. Walters, S. T. Grey, S. V. Watt, M. J. Sweet, M. J. Smyth, C. R. Mackay, and F. Mackay (2007)
J. Exp. Med. 204, 1959-1971
   Abstract »    Full Text »    PDF »



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Science. ISSN 0036-8075 (print), 1095-9203 (online)