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Science 21 April 2006:
Vol. 312. no. 5772, pp. 377 - 378
DOI: 10.1126/science.1126903
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Perspectives

PHARMACOLOGY:
Hitting the Hot Spots of Cell Signaling Cascades

John Joseph Grubb Tesmer

Small-molecule inhibitors can bind in several different ways to protein interaction sites on signaling proteins, thereby selecting downstream pathways. This type of targeting may be useful therapeutically.

The author is in the Department of Pharmacology, Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109, USA. E-mail: tesmerjj{at}umich.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of Heterotrimeric G Protein Signaling by a Small Molecule Acting on G{alpha} Subunit.
M. A. Ayoub, M. Damian, C. Gespach, E. Ferrandis, O. Lavergne, O. De Wever, J.-L. Baneres, J.-P. Pin, and G. P. Prevost (2009)
J. Biol. Chem. 284, 29136-29145
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