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Science 31 March 2006:
Vol. 311. no. 5769, pp. 1875 - 1876
DOI: 10.1126/science.1126030
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Perspectives

IMMUNOLOGY:
An Antibody Paradox, Resolved

Martin Prlic and Michael J. Bevan

The immune effect of a cytokine bound to an antibody is paradoxically much stronger than that of the cytokine alone, suggesting a way to lower therapeutic doses and thereby reduce side effects.

The authors are in the Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195-7370, USA. E-mail: mprlic{at}u.washington.edu, mbevan{at}u.washington.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)