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Science 24 March 2006:
Vol. 311. no. 5768, pp. 1721 - 1723
DOI: 10.1126/science.1125884
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Perspectives

BIOMEDICINE:
Lowering LDL--Not Only How Low, But How Long?

Michael S. Brown and Joseph L. Goldstein

People with a mutation in a proteolytic enzyme are at a substantially lower risk for coronary heart disease because of their lifelong reduction of plasma low-density lipoprotein.

The authors are in the Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9046, USA. Email: mike.brown{at}utsouthwestern.edu, joe.goldstein{at}utsouthwestern.edu

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PCSK9 function and physiology.
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Promise of Low-Density Lipoprotein-Lowering Therapy for Primary and Secondary Prevention.
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Circulation 117, 569-573
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Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis.
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Update on Dyslipidemia.
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Genetic susceptibility to myocardial infarction and coronary artery disease.
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