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Science 24 March 2006:
Vol. 311. no. 5768, pp. 1688 - 1689
DOI: 10.1126/science.311.5768.1688
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News of the Week

DRUG TRIALS:
Violent Reaction to Monoclonal Antibody Therapy Remains a Mystery

Eliot Marshall

CAMBRIDGE, U.K.--On 13 March, six healthy volunteers in a clinical trial were injected with a "superagonist," a drug meant to boost a type of T cell in the immune system, and soon all of them became violently ill. Exactly what triggered the reaction is not known. (Read more.)

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ex Vivo Expansion of CD4+CD25+FoxP3+ T Regulatory Cells Based on Synergy between IL-2 and 4-1BB Signaling.
K. G. Elpek, E. S. Yolcu, D. D. H. Franke, C. Lacelle, R.-H. Schabowsky, and H. Shirwan (2007)
J. Immunol. 179, 7295-7304
   Abstract »    Full Text »    PDF »
Biologics in the Pipeline: Large Molecules With High Hopes or Bigger Risks?.
H. Zhou (2007)
J. Clin. Pharmacol. 47, 550-552
   Full Text »    PDF »
Molecular, Biologic, and Pharmacokinetic Properties of Monoclonal Antibodies: Impact of These Parameters on Early Clinical Development.
M. A. Mascelli, H. Zhou, R. Sweet, J. Getsy, H. M. Davis, M. Graham, and D. Abernethy (2007)
J. Clin. Pharmacol. 47, 553-565
   Abstract »    Full Text »    PDF »
Cytokine-Mediated Disruption of Lymphocyte Trafficking, Hemopoiesis, and Induction of Lymphopenia, Anemia, and Thrombocytopenia in Anti-CD137-Treated Mice.
L. Niu, S. Strahotin, B. Hewes, B. Zhang, Y. Zhang, D. Archer, T. Spencer, D. Dillehay, B. Kwon, L. Chen, et al. (2007)
J. Immunol. 178, 4194-4213
   Abstract »    Full Text »    PDF »
Regulatory T Cell Vaccination without Autoantigen Protects against Experimental Autoimmune Encephalomyelitis.
J. Ochoa-Reparaz, C. Riccardi, A. Rynda, S. Jun, G. Callis, and D. W. Pascual (2007)
J. Immunol. 178, 1791-1799
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)