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Science 10 March 2006:
Vol. 311. no. 5766, pp. 1385 - 1386
DOI: 10.1126/science.1125246
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Perspectives

BIOMEDICINE:
One Misfolded Protein Allows Others to Sneak By

Gillian P. Bates

Proteins prone to aggregate in cells have been linked to neurodegenerative diseases. As cells try to eliminate such aggregates, other misfolded proteins may go undetected, making the cell susceptible to their toxic effects.

The author is at King's College London School of Medicine, London SE1 9RT, UK. E-mail: gillian.bates{at}genetics.kcl.ac.uk

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H. Adachi, M. Waza, K. Tokui, M. Katsuno, M. Minamiyama, F. Tanaka, M. Doyu, and G. Sobue (2007)
J. Neurosci. 27, 5115-5126
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Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression.
T. Lamitina, C. G. Huang, and K. Strange (2006)
PNAS 103, 12173-12178
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ALS protein
Heikki Savolainen
Science Online, 22 Mar 2006 [Full text]

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