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Science 10 March 2006:
Vol. 311. no. 5766, pp. 1382 - 1383
DOI: 10.1126/science.1125298
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Perspectives

BIOCHEMISTRY:
Five Golden Rings

David W. Christianson

The antibiotic nisin bears five rings of different sizes in its structure. The enzyme that catalyzes the five distinct cyclization reactions is flexible, yet stringent, enough to form each ring in the correct order and conformation.

The author is at the Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104-6323, USA. E-mail: chris{at}sas.upenn.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Comment on "A G Protein Coupled Receptor Is a Plasma Membrane Receptor for the Plant Hormone Abscisic Acid".
C. A. Johnston, B. R. Temple, J.-G. Chen, Y. Gao, E. N. Moriyama, A. M. Jones, D. P. Siderovski, and F. S. Willard (2007)
Science 318, 914c
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