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Science 10 February 2006:
Vol. 311. no. 5762, pp. 789 - 790
DOI: 10.1126/science.1124620
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Perspectives

CELL SIGNALING:
A Sophisticated Scaffold Wields a New Trick

Ashton Breitkreutz and Mike Tyers

Many cellular processes are governed by proteins that are docked onto a scaffold protein. In addition to providing binding sites, scaffolds influence the signaling output of these multiprotein complexes.

A. Breitkreutz is with the Campbell Family Institute for Breast Cancer Research, Toronto Medical Discovery Tower, Toronto, Canada M5G 1L7. E-mail: abreitkr{at}uhnres.utoronto.ca M. Tyers is at the Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, Toronto, Canada M5G 1X5. E-mail: tyers{at}mshri.on.ca

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Science. ISSN 0036-8075 (print), 1095-9203 (online)