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Science 27 January 2006:
Vol. 311. no. 5760, pp. 475 - 476
DOI: 10.1126/science.1123883
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Perspectives

BIOCHEMISTRY:
Loop Grafting and the Origins of Enzyme Species

Dan S. Tawfik

An enzyme with completely new function can be created in the lab by mimicking natural evolutionary processes that both alter and preserve protein architecture.

The author is in the Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel. E-mail: tawfik{at}weizmann.ac.il

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Science. ISSN 0036-8075 (print), 1095-9203 (online)