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Science 20 January 2006:
Vol. 311. no. 5759, p. 299
DOI: 10.1126/science.311.5759.299k
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This Week in Science
During cell division, chromosomes must establish connections to the opposing spindle poles and become positioned at the spindle equator. Uncorrected errors in this biorientation inevitably lead to aneuploidy and are associated with cell transformation and cancers. How chromosomes attach properly to the mitotic apparatus is not understood. Kapoor et al. (p. 388; see the cover and the Perspective by Heald) used live-cell two-color fluorescence, correlative light and electron microscopy, as well as chemical biology, to demonstrate surprisingly that chromosomes can congress to the spindle equator before they become bioriented. During congression, the leading kinetochore glides alongside kinetochore fibers of other already bioriented chromosomes toward microtubule plus ends. The gliding is mediated by the kinetochore-associated motor protein. Thus, cells possess a mechanism for repositioning monooriented chromosomes from the periphery to central areas of the spindle where they can establish connections to the other spindle pole.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
