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Science 6 January 2006:
Vol. 311. no. 5757, p. 12
DOI: 10.1126/science.311.5757.12o
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This Week in Science
Dendritic cells (DCs) and macrophages of the immune system have distinct and overlapping functions--DCs are pivotal in initiating and modulating immune responses through the uptake and presentation of antigen to T cells, whereas macrophages clear pathogens through phagocytosis and share some antigen-presenting capacity. Exactly how these cells are developmentally related is unclear. Fogg et al. (p. 83, published online 1 December 2005) identify a common progenitor cell that can be induced to generate DCs and macrophages in culture and produces subsets of both cells when transferred into mice. This common ancestry has many implications for understanding the developmental pathways required for the steady-state production of each type of cell and for their respective roles in immunity.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
