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Science 25 November 2005:
Vol. 310. no. 5752, pp. 1288 - 1289
DOI: 10.1126/science.1121566
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Perspectives

DEVELOPMENTAL BIOLOGY:
Enhanced: Encountering MicroRNAs in Cell Fate Signaling

Xantha Karp and Victor Ambros

The recent discovery of short regulatory RNAs called microRNAs has expanded our understanding of the regulation of gene expression, yet little is known about the role of microRNAs in developmental signaling pathways. In their Perspective, Karp and Ambros discuss a new study by Yoo and Greenwald that finds a microRNA to be a direct target of LIN-12/Notch signaling. This influences cell fate decisions during C. elegans development and may extend to other organisms, because the Notch signaling pathway is highly conserved.

The authors are in the Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA. E-mail: victor.r.ambros{at}dartmouth.edu; xantha.e.karp{at}dartmouth.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke.
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FASEB J 23, 806-812
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Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation.
L.-L. Wang, Z. Zhang, Q. Li, R. Yang, X. Pei, Y. Xu, J. Wang, S.-F. Zhou, and Y. Li (2009)
Hum. Reprod. 24, 562-579
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UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.
C. Taccioli, E. Fabbri, R. Visone, S. Volinia, G. A. Calin, L. Y. Fong, R. Gambari, A. Bottoni, M. Acunzo, J. Hagan, et al. (2009)
Nucleic Acids Res. 37, D41-D48
   Abstract »    Full Text »    PDF »
A MicroRNA Signature of Hypoxia.
R. Kulshreshtha, M. Ferracin, S. E. Wojcik, R. Garzon, H. Alder, F. J. Agosto-Perez, R. Davuluri, C.-G. Liu, C. M. Croce, M. Negrini, et al. (2007)
Mol. Cell. Biol. 27, 1859-1867
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