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Science 25 November 2005:
Vol. 310. no. 5752, pp. 1284 - 1285
DOI: 10.1126/science.1121906
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Perspectives

CELL SIGNALING:
Frizzled at the Cutting Edge of the Synapse

Alfonso Martinez Arias

DFrizzled2 is a Drosophila member of the Frizzled family of Wnt receptors. In his Perspective, Arias discusses the findings by Mathew et al. of Wingless association with DFrizzled2 in the fly neuromuscular junction. The interaction results in a surprising cleavage of the receptor's intracellular domain, an event that is required for the maturation of synaptic structures. This cleavage represents a novel modality of Wnt signaling, a pervasive pathway in animal development.

The author is in the Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK. E-mail: ama11{at}hermes.cam.ac.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)