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Science 18 November 2005:
Vol. 310. no. 5751, pp. 1128 - 1129
DOI: 10.1126/science.1121114
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Perspectives

GENETICS:
Two Genes Link Two Distinct Psychoses

Akira Sawa and Solomon H. Snyder

Disrupted in schizophrenia 1 (DISC1), the first gene directly linked to schizophrenia, appears to regulate neuronal growth and migration. In their Perspective, Sawa and Snyder discuss the study by Millar et al. that reports the interaction of DISC1 with the enzyme phosphodiesterase 4B (PDE4B). PDE4B is now reported as aberrant in a schizophrenic family. The interaction of the two proteins controls PDE4B activity and may modulate mood and mentation both physiologically and pathophysiologically.

The authors are in the Departments of Psychiatry and Neuroscience and the Program in Cellular Molecular Medicine, and S. H. Snyder is also in the Department of Pharmacology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. E-mail: asawa1{at}jhmi.edu; ssnyder{at}jhmi.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Review of Pathological Hallmarks of Schizophrenia: Comparison of Genetic Models With Patients and Nongenetic Models.
H. Jaaro-Peled, Y. Ayhan, M. V. Pletnikov, and A. Sawa (2009)
Schizophr Bull
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NMDA Receptor Phosphorylation at a Site Affected in Schizophrenia Controls Synaptic and Behavioral Plasticity.
B. Li, N. Devidze, D. Barengolts, N. Prostak, E. Sphicas, A. J. Apicella, R. Malinow, and E. S. Emamian (2009)
J. Neurosci. 29, 11965-11972
   Abstract »    Full Text »    PDF »
An Odor-Specific Threshold Deficit Implicates Abnormal Intracellular Cyclic AMP Signaling in Schizophrenia.
B. I. Turetsky and P. J. Moberg (2009)
Am J Psychiatry 166, 226-233
   Abstract »    Full Text »    PDF »
From the Cover: Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.
T. Hikida, H. Jaaro-Peled, S. Seshadri, K. Oishi, C. Hookway, S. Kong, D. Wu, R. Xue, M. Andrade, S. Tankou, et al. (2007)
PNAS 104, 14501-14506
   Abstract »    Full Text »    PDF »
DISC1 Regulates the Transport of the NUDEL/LIS1/14-3-3{varepsilon} Complex through Kinesin-1.
S. Taya, T. Shinoda, D. Tsuboi, J. Asaki, K. Nagai, T. Hikita, S. Kuroda, K. Kuroda, M. Shimizu, S. Hirotsune, et al. (2007)
J. Neurosci. 27, 15-26
   Abstract »    Full Text »    PDF »
Schizophrenia in Translation: Disrupted in Schizophrenia (DISC1): Integrating Clinical and Basic Findings.
R. C. Roberts (2007)
Schizophr Bull 33, 11-15
   Abstract »    Full Text »    PDF »
DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1.
A. Kamiya, T. Tomoda, J. Chang, M. Takaki, C. Zhan, M. Morita, M. B. Cascio, S. Elashvili, H. Koizumi, Y. Takanezawa, et al. (2006)
Hum. Mol. Genet. 15, 3313-3323
   Abstract »    Full Text »    PDF »

E-Letters:

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PDE4 inhibitors: Potential schizophrenia therapeutics?
David Gurwitz, et al.
Science Online, 17 Feb 2006 [Full text]

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