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Science 18 November 2005:
Vol. 310. no. 5751, pp. 1124 - 1125
DOI: 10.1126/science.1121310
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Perspectives

CELL BIOLOGY:
Twists in the Tale of the Aging Yeast

Jasper Rine

Aging limits the number of divisions available to cells and the chronological life span of nondividing cells. In his Perspective, Rine discusses recent findings that caloric restriction, SIR2, and its molecular cousins, play conserved roles in aging. However, expectations of a simple unified model linking caloric restriction and aging through Sir2 protein's NAD cofactor are now on hold.

The author is in the Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. E-mail: jrine{at}berkeley.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology..
D. Anastasiou and W. Krek (2006)
Physiology 21, 404-410
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)