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BIOMEDICINE: Separation of Conjoined Hormones Yields Appetite Rivals
Ruben Nogueiras and Matthias Tschöp
In their Perspective, Nogueiras and Tschöp discuss the study of Zhang et al. that has identified obestatin, a new hormone regulator of energy balance. Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents. The paradox is that obestatin is derived from a precursor peptide that also yields ghrelin, a hormone that increases appetite and body weight.
The authors are in the Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA, and the Department of Pharmacology, German Institute of Human Nutrition, 14558 Nuthetal, Germany. E-mail: tschoemh{at}ucmail.uc.edu
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In Science Magazine
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Jian V. Zhang, Pei-Gen Ren, Orna Avsian-Kretchmer, Ching-Wei Luo, Rami Rauch, Cynthia Klein, and Aaron J. W. Hsueh (11 November 2005) Science310 (5750), 996.
[DOI: 10.1126/science.1117255] |Abstract »|Full Text »|PDF »|Supporting Online Material »
Normal Food Intake and Body Weight in Mice Lacking the G Protein-Coupled Receptor GPR39.
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GPR39 Signaling Is Stimulated by Zinc Ions But Not by Obestatin.
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148, 13-20
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