Related Content
Search Google Scholar for:
More Information
Related Jobs from ScienceCareers
|
|
Science 4 November 2005:
Vol. 310. no. 5749, pp. 791 - 793
DOI: 10.1126/science.1114394
|
|
Perspectives
NEUROSCIENCE:
The Neuron Doctrine, Redux
Theodore H. Bullock, Michael V. L. Bennett, Daniel Johnston, Robert Josephson, Eve Marder, R. Douglas Fields
In their Perspective, Bullock et al. discuss recent evidence suggesting that the Neuron Doctrine, conceived nearly a century ago, cannot encompass important aspects of information processing in the brain. Intercellular communication by gap junctions, slow electrical potentials, action potentials initiated in dendrites, neuromodulatory effects, extrasynaptic release of neurotransmitters, and information flow between neurons and glia all contribute to information processing. Revisiting the Neuron Doctrine suggests that future research outside its limits may lead to new insights into the unique capabilities of the human brain.
T. H. Bullock is at the Scripps Institution of Oceanography and Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA. M. V. L. Bennett is in the Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. D. Johnston is at the Center for Learning and Memory, University of Texas, Austin, TX 78712, USA. R. Josephson is in the Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA. E. Marder is in the Department of Biology, Brandeis University, Waltham, MA 02454, USA. R. D. Fields is in the Nervous Systems Development and Plasticity Section, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. E-mail: fieldsd{at}mail.nih.gov
Read the Full Text
|
|
