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Science 14 October 2005:
Vol. 310. no. 5746, pp. 247 - 248
DOI: 10.1126/science.1120154
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Perspectives

GENETICS:
Motivating Hotspots

Molly Przeworski

Only recently have we begun to characterize fine-scale recombination rates in mammals. In her Perspective, Przeworski discusses the work by Myers et al. in which linkage disequilibrium data have been used to produce a high-resolution recombination map for most of the human genome. More than 25,000 putative hotspots have been identified, as well as the first motifs that appear to influence their intensity.

The author is in the Department of Human Genetics, University of Chicago, 920 East 57th Street, 507F CLSC, Chicago, IL 60637, USA. E-mail: mfp{at}uchicago.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Using Crossover Breakpoints in Recombinant Inbred Lines to Identify Quantitative Trait Loci Controlling the Global Recombination Frequency.
E. Esch, J. M. Szymaniak, H. Yates, W. P. Pawlowski, and E. S. Buckler (2007)
Genetics 177, 1851-1858
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Science. ISSN 0036-8075 (print), 1095-9203 (online)