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of Science's Enhanced Perspectives and Policy Forums
CELL BIOLOGY: Enhanced: A Fungal Achilles' Heel
Joseph Heitman
The ability of pathogenic microbes to rapidly acquire resistance to antimicrobial agents is a serious threat to human health. In a Perspective, Heitman discusses the study by Cowen and Lindquist (in this issue) that defines a role for two proteins, Hsp90 and calcineurin, in drug tolerance and resistance in pathogenic fungi, providing a novel therapeutic foothold.
The author is in the Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. E-mail: heitm001{at}duke.edu
Efungumab and caspofungin: pre-clinical data supporting synergy.
S. Hodgetts, L. Nooney, R. Al-Akeel, A. Curry, S. Awad, R. Matthews, and J. Burnie (2008)
J. Antimicrob. Chemother.
61, 1132-1139
|Abstract »|Full Text »|PDF »
Genome-Wide Analysis of Sterol-Lipid Storage and Trafficking in Saccharomyces cerevisiae.
W. Fei, G. Alfaro, B.-P. Muthusamy, Z. Klaassen, T. R. Graham, H. Yang, and C. T. Beh (2008)
Eukaryot. Cell
7, 401-414
|Abstract »|Full Text »|PDF »
High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections.
L. Zhang, K. Yan, Y. Zhang, R. Huang, J. Bian, C. Zheng, H. Sun, Z. Chen, N. Sun, R. An, et al. (2007)
PNAS
104, 4606-4611
|Abstract »|Full Text »|PDF »
