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Science 30 September 2005:
Vol. 309. no. 5744, pp. 2170 - 2171
DOI: 10.1126/science.1116204
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Policy Forum

AIDS:
Promote HIV Chemoprophylaxis Research, Don't Prevent It

Robert M. Grant,1,2* Susan Buchbinder,2,3 Willard Cates Jr.,4 Edith Clarke,5 Thomas Coates,6 Myron S. Cohen,7 Martin Delaney,8 Guiselly Flores,9 Pedro Goicochea,10 Gregg Gonsalves,11 Mark Harrington,12 Javier R. Lama,10 Kathleen M. MacQueen,4 John P. Moore,13 Leigh Peterson,4 Jorge Sanchez,10 Melanie Thompson,14 Mark A. Wainberg15

Preexposure chemoprophylaxis (PrEP) is a promising approach to HIV-1 prevention that warrants clinical evaluation, especially in regions of the world hit hardest by the epidemic. Controversy has arisen that highlights the needs of high-risk populations who frequently have limited access to information and medical care. The authors of this Policy Forum recommend involvement of community leaders and local investigators early in the development of research projects, open communication of accurate information about research, and active development of prevention and treatment infrastructure, which all serve to build the community trust that is the basis for research into finding ways to stop the spread of HIV/AIDS.

1Gladstone Institute of Virology and Immunology, San Francisco, CA, USA. 2University of California at San Francisco, CA, USA. 3San Francisco Department of Public Health, CA, USA. 4Family Health International, Research Triangle Park, NC, USA. 5Ghana Health Service, Accra, Ghana. 6University of California at Los Angeles, CA, USA. 7University of North Carolina, Chapel Hill, NC, USA. 8Project Inform, San Francisco, CA, USA. 9Red Peruana de Mujeres que Viven con VIH/Sida; 10Asociación Civil Impacta Salud y Educación, Lima, Peru. 11Gay Men's Health Crisis, New York, NY; 12Treatment Action Group, New York, NY, USA. 13Weill Medical College of Cornell University, New York, NY, USA. 14AIDS Research Consortium of Atlanta, GA, USA. 15McGill University AIDS Center, Montreal, Quebec, Canada.

*Author for correspondence. E-mail: rgrant{at}itsa.ucsf.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)