GENETICS: Mouse With Human Chromosome Should Boost Down Syndrome Research

doi:10.1126/science.309.5743.1975a

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Science 23 September 2005:
Vol. 309. no. 5743, p. 1975
DOI: 10.1126/science.309.5743.1975a

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GENETICS:
Mouse With Human Chromosome Should Boost Down Syndrome Research

Greg Miller

On page 2033 of this issue of Science, researchers report creating a strain of mice with a nearly complete copy of human chromosome 21. The strain's unusual genome mimics the genetic makeup of people with Down syndrome, the most common inherited form of mental retardation.

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RESEARCH ARTICLES An Aneuploid Mouse Strain Carrying Human Chromosome 21 with Down Syndrome Phenotypes: Aideen O'Doherty, Sandra Ruf, Claire Mulligan, Victoria Hildreth, Mick L. Errington, Sam Cooke, Abdul Sesay, Sonie Modino, Lesley Vanes, Diana Hernandez, Jacqueline M. Linehan, Paul T. Sharpe, Sebastian Brandner, Timothy V. P. Bliss, Deborah J. Henderson, Dean Nizetic, Victor L. J. Tybulewicz, and Elizabeth M. C. Fisher (23 September 2005)
Science 309 (5743), 2033. [DOI: 10.1126/science.1114535]
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Science. ISSN 0036-8075 (print), 1095-9203 (online)

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