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Science 16 September 2005:
Vol. 309. no. 5742, pp. 1826 - 1827
DOI: 10.1126/science.1118828
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Perspectives

IMMUNOLOGY:
Insects Diversify One Molecule to Serve Two Systems

Louis Du Pasquier

In his Perspective, Du Pasquier discusses findings of Watson et al. that alternate splicing of the locus encoding the insect homolog of the Down syndrome cell adhesion molecule generates a vast diversity of immunoglobulin superfamily receptors used in the nervous system and in the immune system. Du Pasquier discusses the implications of this situation for the regulation and the evolution of this locus.

The author is at the Institute of Zoology and Evolutionary Biology, University of Basel, Vesalgasse 1, CH-4051 Basel, Switzerland. E-mail: dupasquier{at}dial.eunet.ch

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Dscam Homologue of the Crustacean Daphnia Is Diversified by Alternative Splicing Like in Insects.
D. Brites, S. McTaggart, K. Morris, J. Anderson, K. Thomas, I. Colson, T. Fabbro, T. J. Little, D. Ebert, and L. Du Pasquier (2008)
Mol. Biol. Evol. 25, 1429-1439
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Science. ISSN 0036-8075 (print), 1095-9203 (online)