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Science 26 August 2005:
Vol. 309. no. 5739, pp. 1334 - 1335
DOI: 10.1126/science.1117842
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Perspectives

CELL BIOLOGY:
A Gradient Signal Orchestrates the Mitotic Spindle

Paul R. Clarke

Assembly of the mitotic spindle is critical for the proper segregation of chromosomes during cell division. In his Perspective, Clarke discusses work by Caudron et al. (in the same issue) that shows how generation at chromosomes of a chemical gradient of Ran-GTP directs microtubule nucleation and growth during spindle assembly. The findings suggest a general principle for the spatial control of intracellular organization.

The author is with the Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK. E-mail: paul.clarke{at}cancer.org.uk

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Misregulation of the Kinesin-like Protein Subito Induces Meiotic Spindle Formation in the Absence of Chromosomes and Centrosomes.
J. K. Jang, T. Rahman, V. S. Kober, J. Cesario, and K. S. McKim (2007)
Genetics 177, 267-280
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Science. ISSN 0036-8075 (print), 1095-9203 (online)