Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 5 August 2005:
Vol. 309. no. 5736, pp. 886 - 887
DOI: 10.1126/science.1116801
Prev | Table of Contents | Next

Perspectives

CANCER:
Suppressing Cancer: The Importance of Being Senescent

Judith Campisi

Cellular senescence permanently arrests the cell division cycle and has long been thought to prevent the growth of cells at risk for transformation into cancer cells. In her Perspective, Campisi discusses recent evidence that cellular senescence indeed limits the development of malignant cancers in mice and humans.

Lawrence Berkeley National Laboratory, Life Sciences Division, 1 Cyclotron Road, Berkeley, CA 94720 and Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA. E-mail: jcampisi{at}lbl.gov

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Senescence-Associated Exosome Release from Human Prostate Cancer Cells.
B. D. Lehmann, M. S. Paine, A. M. Brooks, J. A. McCubrey, R. H. Renegar, R. Wang, and D. M. Terrian (2008)
Cancer Res. 68, 7864-7871
   Abstract »    Full Text »    PDF »
PPAR{gamma} accelerates cellular senescence by inducing p16INK4{alpha} expression in human diploid fibroblasts.
Q. Gan, J. Huang, R. Zhou, J. Niu, X. Zhu, J. Wang, Z. Zhang, and T. Tong (2008)
J. Cell Sci. 121, 2235-2245
   Abstract »    Full Text »    PDF »
Protumorigenic Effects of the Senescence-Associated Secretory Phenotype.
J. Campisi (2008)
Am. Assoc. Cancer Res. Educ. Book 2008, 505-509
   Abstract »    Full Text »    PDF »
UVB-induced Senescence in Human Keratinocytes Requires a Functional Insulin-like Growth Factor-1 Receptor and p53.
D. A. Lewis, Q. Yi, J. B. Travers, and D. F Spandau (2008)
Mol. Biol. Cell 19, 1346-1353
   Abstract »    Full Text »    PDF »
An Oncogene-Induced DNA Damage Model for Cancer Development.
T. D. Halazonetis, V. G. Gorgoulis, and J. Bartek (2008)
Science 319, 1352-1355
   Abstract »    Full Text »    PDF »
DEC1, a Basic Helix-Loop-Helix Transcription Factor and a Novel Target Gene of the p53 Family, Mediates p53-dependent Premature Senescence.
Y. Qian, J. Zhang, B. Yan, and X. Chen (2008)
J. Biol. Chem. 283, 2896-2905
   Abstract »    Full Text »    PDF »
The Ataxia Telangiectasia Mutated Target Site Ser18 Is Required for p53-Mediated Tumor Suppression.
H. L. Armata, D. S. Garlick, and H. K. Sluss (2007)
Cancer Res. 67, 11696-11703
   Abstract »    Full Text »    PDF »
Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia.
E. L. Bell, T. A. Klimova, J. Eisenbart, P. T. Schumacker, and N. S. Chandel (2007)
Mol. Cell. Biol. 27, 5737-5745
   Abstract »    Full Text »    PDF »
Endothelial senescence after high-cholesterol, high-fat diet challenge in baboons.
Q. Shi, G. B. Hubbard, R. S. Kushwaha, D. Rainwater, C. A. Thomas III, M. M. Leland, J. L. VandeBerg, and X. L. Wang (2007)
Am J Physiol Heart Circ Physiol 292, H2913-H2920
   Abstract »    Full Text »    PDF »
MMP-9 Short Interfering RNA Induced Senescence Resulting in Inhibition of Medulloblastoma Growth via p16INK4a and Mitogen-Activated Protein Kinase Pathway.
J. S. Rao, P. Bhoopathi, C. Chetty, M. Gujrati, and S. S. Lakka (2007)
Cancer Res. 67, 4956-4964
   Abstract »    Full Text »    PDF »
SV40 Oncoproteins Enhance Asbestos-Induced DNA Double-Strand Breaks and Abrogate Senescence in Murine Mesothelial Cells.
J. R. Pietruska and A. B. Kane (2007)
Cancer Res. 67, 3637-3645
   Abstract »    Full Text »    PDF »
The HBP1 Transcriptional Repressor Participates in RAS-Induced Premature Senescence.
X. Zhang, J. Kim, R. Ruthazer, M. A. McDevitt, D. E. Wazer, K. E. Paulson, and A. S. Yee (2006)
Mol. Cell. Biol. 26, 8252-8266
   Abstract »    Full Text »    PDF »
The Human Orthologue of Drosophila Ecdysoneless Protein Interacts with p53 and Regulates Its Function..
Y. Zhang, C. B. Gurumurthy, J. Kim, I. Bhat, Q. Gao, G. Dimri, S. W. Lee, H. Band, and V. Band (2006)
Cancer Res. 66, 7167-7175
   Abstract »    Full Text »    PDF »
Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence..
T. Yan, Y. Seo, J. E. Schupp, X. Zeng, A. B. Desai, and T. J. Kinsella (2006)
Mol. Cancer Ther. 5, 893-902
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)