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Science 5 August 2005:
Vol. 309. no. 5736, p. 847
DOI: 10.1126/science.309.5736.847h
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This Week in Science

Certain plants carry resistance (R) genes variants that match a particular pathogen's virulence factor. However, too much or too little of the R protein can send the plant's immune response haywire. Holt et al. (p. 929, published online 23 June 2005) now provide a genetic analysis of some of the factors that keep the immune response in Arabidopsis primed for a rapid deployment but not running rampant. One component, RAR1, somehow promotes the accumulation of the R proteins, and another, SGT1, interacts with RAR1, antagonizing its activity. SGT1 does double duty in infected plants by regulating the cell death response that limits the damage done by some pathogens.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)