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Science 29 July 2005:
Vol. 309. no. 5735, pp. 709 - 710
DOI: 10.1126/science.1116630
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Perspectives

Also see the archival list of Science's Enhanced Perspectives and Policy Forums

MICROBIOLOGY:
Enhanced: Translocation of Anthrax Toxin: Lord of the Rings

Gunnar von Heijne[HN11]

Many microorganisms have evolved ingenious ways of shipping toxic proteins into target cells. In his Perspective, von Heijne discusses a study by Krantz et al. that reveals how anthrax toxin gets into a cell. A ring of aromatic amino acids in a pore formed by anthrax toxin helps unfold other anthrax toxin proteins and facilitate their translocation across the cell membrane.

The author is in the Department of Biochemistry and Biophysics, Stockholm University, SE-10691 Stockholm, Sweden. E-mail: gunnar{at}dbb.su.se

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Science. ISSN 0036-8075 (print), 1095-9203 (online)