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Science 22 July 2005:
Vol. 309. no. 5734, p. 532
DOI: 10.1126/science.309.5734.532j
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This Week in Science

What are the causes, constraints, and consequences of chromosome rearrangements? Murphy et al. (p. 613) used genome sequences and high-density comparative maps from eight species within five mammalian orders to infer evolutionary processes influencing chromosome dynamics. Chromosomal breakpoints tended to be reused during evolution, and there has been an increase in the rates of mammalian chromosome breakage since the Late Cretaceous period. Centromeres tended to be associated with reuse breakpoints. Forty breakpoints were identified as primate-specific, and nearly all involved segmental duplications.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)