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Science 1 July 2005:
Vol. 309. no. 5731, p. 80
DOI: 10.1126/science.309.5731.80
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Why Do Humans Have So Few Genes?

Elizabeth Pennisi

The discovery that humans have far fewer genes than was assumed prior to the completion of the human genome project has reinforced a growing realization that our genomes and those of other mammals are far more flexible and complicated than they once seemed.

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Promoting transcriptome diversity.
R. L. Strausberg and S. Levy (2007)
Genome Res. 17, 965-968
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The implications of alternative splicing in the ENCODE protein complement.
M. L. Tress, P. L. Martelli, A. Frankish, G. A. Reeves, J. J. Wesselink, C. Yeats, P. l. Olason, M. Albrecht, H. Hegyi, A. Giorgetti, et al. (2007)
PNAS 104, 5495-5500
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Science. ISSN 0036-8075 (print), 1095-9203 (online)