Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Also see the archival list of Science's Enhanced Perspectives and Policy Forums
BIOMEDICINE: Enhanced: The Anti-Aging Sweepstakes: Catalase Runs for the ROSes
Richard A. Miller
In a Perspective, Miller discusses new data on transgenic mice showing that better antioxidative defenses can boost life span in a mammal. Other long-lived mutants, in contrast, resist multiple forms of cell injury, and mutants with low oxidation resistance can nonetheless retain normal longevity. Comparisons among long- and short-lived species could reveal new links between stress resistance and aging.
The author is in the Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, and Ann Arbor DVA Medical Center, Ann Arbor, MI 48109-0940, USA. E-mail: millerr{at}umich.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Samuel E. Schriner, Nancy J. Linford, George M. Martin, Piper Treuting, Charles E. Ogburn, Mary Emond, Pinar E. Coskun, Warren Ladiges, Norman Wolf, Holly Van Remmen, Douglas C. Wallace, and Peter S. Rabinovitch (24 June 2005) Science308 (5730), 1909.
[DOI: 10.1126/science.1106653] |Abstract »|Full Text »|PDF »|Supporting Online Material »
Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification.
K. Morita, T. Miyamoto, N. Fujita, Y. Kubota, K. Ito, K. Takubo, K. Miyamoto, K. Ninomiya, T. Suzuki, R. Iwasaki, et al. (2007)
J. Exp. Med.
204, 1613-1623
|Abstract »|Full Text »|PDF »
Estrogen and mitochondria: a new paradigm for vascular protection?.
S. P. Duckles, D. N. Krause, C. Stirone, and V. Procaccio (2006)
Mol. Interv.
6, 26-35
|Abstract »|Full Text »|PDF »
