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Science 3 June 2005:
Vol. 308. no. 5727, pp. 1420 - 1421
DOI: 10.1126/science.1114168
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Perspectives

CELL BIOLOGY:
Prion Toxicity: All Sail and No Anchor

Adriano Aguzzi

Cellular prion proteins are converted into an aggregated, neurotoxic form when cells are attacked by infectious prion particles. In his Perspective, Aguzzi discusses new insights into prion disease progression. Genetically altered mice that express a secreted form of prion protein never succumb to disease, even though prion aggregates form in their brains.

The author is at the Institute of Neuropathology, University Hospital of Zürich, CH-8091 Zürich, Switzerland. E-mail: adriano{at}pathol.unizh.ch

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis.
A. D. Steele, J. G. Emsley, P. H. Ozdinler, S. Lindquist, and J. D. Macklis (2006)
PNAS 103, 3416-3421
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E-Letters:

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Transmissible Spongiform Encephalopathy and Beyond
Wen-Quan Zou
Science Online, 20 Sep 2007 [Full text]

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Science. ISSN 0036-8075 (print), 1095-9203 (online)