Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 May 2005:
Vol. 308. no. 5726, pp. 1266 - 1267
DOI: 10.1126/science.1113707
Prev | Table of Contents | Next

Perspectives

CELL BIOLOGY:
Lessons in Rational Drug Design for Protein Kinases

Natalie G. Ahn and Katheryn A. Resing

A Holy Grail of marrying bioinformatics with structural biology is the design of drugs that precisely affect specific cellular targets. Ahn and Resing discuss in their Perspective how combining sequence and structural analysis of the catalytic site of protein kinases allowed one group to rationally design molecules that selectively block p90 ribosomal S6 kinase enzymatic activity in cells.
The authors are in the Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA. E-mail: natalie.ahn{at}colorado.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.
S. Betzi, A. Restouin, S. Opi, S. T. Arold, I. Parrot, F. Guerlesquin, X. Morelli, and Y. Collette (2007)
PNAS 104, 19256-19261
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)