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Science 20 May 2005:
Vol. 308. no. 5725, pp. 1123 - 1124
DOI: 10.1126/science.1113415
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Perspectives

MOLECULAR BIOLOGY:
A Renewed Focus on Transfer RNA

Tina Daviter, Frank V. Murphy IV, V. Ramakrishnan

Decoding of the genetic message involves both the ribosome and its tRNA substrates. Most studies on the details of this process have focused on the role of the ribosome. In their Perspective, Daviter et al. discuss new work (Cochella and Green) that shows how the properties of tRNA influence its own selection.

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. E-mail: ramak{at}mrc-lmb.cam.ac.uk

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Conserved Loop Sequence of Helix 69 in Escherichia coli 23 S rRNA Is Involved in A-site tRNA Binding and Translational Fidelity.
N. Hirabayashi, N. S. Sato, and T. Suzuki (2006)
J. Biol. Chem. 281, 17203-17211
   Abstract »    Full Text »    PDF »
Identification of Functionally Important Amino Acids of Ribosomal Protein L3 by Saturation Mutagenesis.
A. Meskauskas, A. N. Petrov, and J. D. Dinman (2005)
Mol. Cell. Biol. 25, 10863-10874
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)