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Science 22 April 2005:
Vol. 308. no. 5721, pp. 504 - 506
DOI: 10.1126/science.1110535
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Perspectives

CELL BIOLOGY:
A Fishing Buddy for Hypothesis Generators

Roger Brent and Larry Lok

Understanding how signaling proteins interact in a giant intracellular network to control numerous cellular processes is the goal of many biologists. In their Perspective, Brent and Lok discuss a study that takes us a step closer to accomplishing this goal. The Perspective authors describe the application of Bayesian networks and computational methods to elucidating interactions among the signaling proteins in individual human T cells (Sachs et al.)

The authors are at the Molecular Sciences Institute, Berkeley, CA 94704, USA. E-mail: brent{at}molsci.org, lok{at}molsci.org

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Science. ISSN 0036-8075 (print), 1095-9203 (online)