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CELL BIOLOGY: Kinasing and Clipping Down the NF-B Trail
Nicolai S. C. van Oers and Zhijian J. Chen
Activation of T cells is a key requirement for a successful innate or adaptive immune response to pathogenic insult. T cell stimulation results in activation of the master transcription factor NF-B by a complicated signaling pathway that is only partially understood. In their Perspective, van Oers and Chen discuss new findings that implicate the kinase PDK1 (Lee et al.) and a caspase (Su et al.) as crucial players in the T cell signaling pathway that activates NF-B.
N. S. C. van Oers is in the Department of Microbiology and the Center for Immunology, and Z. J. Chen is in the Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. E-mail: zhijian.chen {at}utsouthwestern.edu
Caspases leave the beaten track: caspase-mediated activation of NF-{kappa}B.
M. Lamkanfi, W. Declercq, T. Vanden Berghe, and P. Vandenabeele (2006)
J. Cell Biol.
173, 165-171
|Abstract »|Full Text »|PDF »
CARMA1 Is Required for Akt-Mediated NF-{kappa}B Activation in T Cells..
P. Narayan, B. Holt, R. Tosti, and L. P. Kane (2006)
Mol. Cell. Biol.
26, 2327-2336
|Abstract »|Full Text »|PDF »
PKC{beta} regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
H. Shinohara, T. Yasuda, Y. Aiba, H. Sanjo, M. Hamadate, H. Watarai, H. Sakurai, and T. Kurosaki (2005)
J. Exp. Med.
202, 1423-1431
|Abstract »|Full Text »|PDF »
B Trail
