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Science 1 April 2005:
Vol. 308. no. 5718, pp. 60 - 62
DOI: 10.1126/science.1110903
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Perspectives

EVOLUTION:
Where We're Hot, They're Not

Lynn B. Jorde

Homologous recombination is the exchange of material between chromosome pairs during meiosis. As Jorde discusses in his Perspective, new work (Winckler et al.) reveals a surprising finding about the recombination hotspots of the human and chimp genomes. Despite about 99% identity between the DNA sequences of these two species, there is virtually no overlap in the locations of recombination hotspots. Jorde discusses the possible reasons for this unexpected finding.

The author is in the Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. E-mail: lbj{at}genetics.utah.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)