Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 March 2005:
Vol. 307. no. 5715, pp. 1570 - 1572
DOI: 10.1126/science.1110533
Prev | Table of Contents | Next

Perspectives

CELL BIOLOGY:
Does Notch Take the Sweet Road to Success?

John B. Lowe

The cell surface receptor Notch is crucial for animal development, and elaborate mechanisms have evolved to control expression of the Notch gene. As Lowe describes in his Perspective, new work (Okajima et al.) now reveals that Notch can be regulated through control of its expression at the cell surface. It turns out that egress of Notch from its site of synthesis in the endoplasmic reticulum and its subsequent transit to the cell surface via the secretory pathway is modulated by the chaperone-like activity of a fucosyltransferase enzyme.

The author is at The Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109-2216, USA. E-mail: johnlowe{at}umich.edu

Read the Full Text

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)