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Science 18 February 2005:
Vol. 307. no. 5712, pp. 1056 - 1058
DOI: 10.1126/science.1109680
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Perspectives

DEVELOPMENTAL BIOLOGY:
Life After Deaf for Hair Cells?

Ruth Taylor and Andrew Forge

Mammals have lost the ability to replace damaged sensory hair cells of the inner ear through the proliferation of remaining hair cells. In a Perspective, Taylor and Forge discuss exciting new work in mice that identifies the retinoblastoma protein as a key regulator of the nonproliferative state of inner ear hair cells (Sage et al.). They postulate that blocking expression of the retinoblastoma protein may form the basis of therapies that could help to treat hearing impairments by coaxing hair cells to proliferate.

The authors are at the Centre for Auditory Research, UCL Ear Institute, University College London, London WC1X 8EE, UK. E-mail: a.forge{at}ucl.ac.uk

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Science. ISSN 0036-8075 (print), 1095-9203 (online)