Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Click Me!

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 18 February 2005:
Vol. 307. no. 5712, pp. 1052 - 1053
DOI: 10.1126/science.1109682
Prev | Table of Contents | Next

Perspectives

GENETICS:
Harvesting Medical Information from the Human Family Tree

David Altshuler and Andrew G. Clark

Working with 71 individuals from three diverse human populations, Hinds et al. have characterized more than 1.5 million individual differences in human DNA sequences. In a Perspective, Altshuler and Clark discuss the significance of these findings, their correlation with data from the International Haplotype Map Project, and what both data sets mean for understanding complex human diseases caused by multiple factors.

D. Altshuler is at the Broad Institute of Harvard and Massachusetts Institute of Technology, and at the Massachusetts General Hospital, Boston, MA 02114, USA. E-mail: altshuler{at}molbio.mgh.harvard.edu A. G. Clark is in the Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. E-mail: ac347{at}cornell.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nonlinear Tests for Genomewide Association Studies.
J. Zhao, L. Jin, and M. Xiong (2006)
Genetics 174, 1529-1538
   Abstract »    Full Text »    PDF »
High-throughput discovery of rare human nucleotide polymorphisms by Ecotilling.
B. J. Till, T. Zerr, E. Bowers, E. A. Greene, L. Comai, and S. Henikoff (2006)
Nucleic Acids Res. 34, e99
   Abstract »    Full Text »    PDF »
Racializing Drug Design: Implications of Pharmacogenomics for Health Disparities.
S. S.-J. Lee (2005)
Am J Public Health 95, 2133-2138
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT

To Advertise     Find Products