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Science 11 February 2005:
Vol. 307. no. 5711, pp. 863 - 864
DOI: 10.1126/science.1110022
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Essays on Science and Society

Also see the archival list of the Essays on Science and Society.

YOUNG SCIENTIST AWARD ESSAY WINNER:
Construction of a Minimal, Protein-Free Spliceosome

Saba Valadkhan

The spliceosome is a complex and dynamic molecular machine that splices pre-messenger RNAs to mature transcripts, a crucial step in eukaryotic gene expression. In her essay that won the Young Scientist Award, Saba Valadkhan describes the construction of a minimal, protein-free spliceosome. Her work provided direct evidence for RNA catalysis in the spliceosome and settled the longstanding question of the identity of the catalytic domain. It provides an elegant example of using designed simple biological systems to address problems not amenable to other approaches.

For the full text of essays by the regional winners and for information about applying for next year's awards, see Science Online at www.sciencemag.org/feature/data/prizes/ge/index.shtml.

The author is at Case Western University, 2109 Adelbert Road, Wood RT 100-8, Cleveland, OH 44106, USA. E-mail: saba.valadkhan{at}case.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)