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Science 24 December 2004:
Vol. 306. no. 5705, pp. 2202 - 2203
DOI: 10.1126/science.1107236
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Perspectives

MICROBIOLOGY:
Peptide Signals Sense and Destroy Target Cells

Danielle A. Garsin

It is well established that bacteria secrete signals enabling them to communicate with other members of the same species and also with other bacterial populations. In an illuminating Perspective, Garsin discusses a cytolysin signal produced by a human pathogen, Enterococcus faecalis, that enables the bacterium to sense host target cells from afar and to ramp up production of cytolysin such that target cells are efficiently lysed (Coburn et al.).

The author is in the Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, TX 77030, USA. E-mail: danielle.a.garsin{at}uth.tmc.edu

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Science. ISSN 0036-8075 (print), 1095-9203 (online)