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Science 26 November 2004:
Vol. 306. no. 5701, pp. 1492 - 1493
DOI: 10.1126/science.1106677
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Perspectives

EVOLUTION:
Epistasis in RNA Viruses

Yannis Michalakis and Denis Roze

An important question yet to be answered in evolutionary biology concerns the benefit of recombination and sexual reproduction. Some theories suggest that recombination has been favored by selection because of the nature of epistatic interactions, where a gene at one locus influences the expression of a gene at a different locus. In their Perspective, Michalakis and Roze discuss two new studies of RNA viruses published here (Bonhoeffer et al.) and elsewhere that report evidence for the presence of positive epistasis in RNA viruses.

The authors are at Génétique et Evolution des Maladies Infectieuses, UMR CNRS IRD 2724, Montpellier Cedex 5, France. E-mail: yannis.michalakis{at}mpl.ird.fr; denis.roze{at}mpl.ird.fr

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Epistasis for Fitness-Related Quantitative Traits in Arabidopsis thaliana Grown in the Field and in the Greenhouse.
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Evolution of Hepatitis Delta Virus RNA Genome following Long-Term Replication in Cell Culture.
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