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Science 26 November 2004:
Vol. 306. no. 5701, pp. 1484 - 1485
DOI: 10.1126/science.1106767
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Perspectives

MOLECULAR BIOLOGY:
A Higher Order of Silence

Adone Mohd-Sarip and C. Peter Verrijzer

It is well-established that compaction of chromatin affects gene expression by regulating the accessibility of DNA to factors that control gene expression. Although the three-dimensional structure of nucleosomes has been elucidated in exquisite detail, the next level of chromatin structure is still poorly understood. In their Perspective, Mohd-Sarip and Verrijzer discuss two new studies (Dorigo et al. and Francis et al.) that shed light on how compaction of the nucleosomes into a higher order structure--a 30-nm chromatin fiber--contributes to the regulation of gene expression.

The authors are in the Department of Biochemistry, Erasmus Medical Center, Rotterdam, Netherlands. E-mail: c.verrijzer{at}erasmusmc.nl

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nuclear reorganisation and chromatin decondensation are conserved, but distinct, mechanisms linked to Hox gene activation.
C. Morey, N. R. Da Silva, P. Perry, and W. A. Bickmore (2007)
Development 134, 909-919
   Abstract »    Full Text »    PDF »
"Genome design" model: Evidence from conserved intronic sequence in human-mouse comparison.
A. E. Vinogradov (2006)
Genome Res. 16, 347-354
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)