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Science 22 October 2004:
Vol. 306. no. 5696, pp. 625 - 626
DOI: 10.1126/science.1101104
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

CHEMISTRY:
Enhanced: Redesigning Genetics

Steven A. Benner

Tinkering with DNA may not seem like a particularly good idea to biologists, but organic chemists seem driven to redesign the genetic code. In his Perspective, Benner discusses the many ways in which organic chemistry can be used to produce artificial DNA molecules that have broad therapeutic applications in diagnostic testing for human diseases.

The author is in the Department of Chemistry, University of Florida, Gainesville, FL 32611, USA. E-mail: benner{at}chem.ufl.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chemical Theory and Computation Special Feature: (G-H){bullet}-C and G-(C-H){bullet} radicals derived from the guanine{middle dot}cytosine base pair cause DNA subunit lesions.
P. P. Bera and H. F. Schaefer III (2005)
PNAS 102, 6698-6703
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)