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Science 15 October 2004:
Vol. 306. no. 5695, pp. 384 - 385
DOI: 10.1126/science.306.5695.384
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News of the Week

DRUG SAFETY:
Withdrawal of Vioxx Casts a Shadow Over COX-2 Inhibitors

Jennifer Couzin

Will other COX-2 inhibitors suffer a fate similar to that of Vioxx, which was recently found to increase the risk of heart attacks and stroke?

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J. Nutr. 138, 2111-2116
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Cardiovascular safety of drugs not intended for cardiovascular use: need for a new conceptual basis for assessment and approval.
J. S. Borer, H. Pouleur, E. Abadie, F. Follath, J. Wittes, M. A. Pfeffer, B. Pitt, and F. Zannad (2007)
Eur. Heart J. 28, 1904-1909
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Thromboxane A2-induced arrhythmias in the anesthetized rabbit.
M. J. Wacker, S. R. Best, L. M. Kosloski, C. J. Stachura, R. L. Smoot, C. B. Porter, and J. A. Orr (2006)
Am J Physiol Heart Circ Physiol 290, H1353-H1361
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Cyclooxygenase inhibitors in urinary bladder cancer: in vitro and in vivo effects..
S. I. Mohammed, D. Dhawan, S. Abraham, P. W. Snyder, D. J. Waters, B. A. Craig, M. Lu, L. Wu, R. Zheng, J. Stewart, et al. (2006)
Mol. Cancer Ther. 5, 329-336
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Informed consent - a new approach to drug regulation?.
D. J. Nutt (2006)
J Psychopharmacol 20, 3-4
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IMPACT OF CYP2C9 GENOTYPE ON PHARMACOKINETICS: ARE ALL CYCLOOXYGENASE INHIBITORS THE SAME?.
A. D. Rodrigues (2005)
Drug Metab. Dispos. 33, 1567-1575
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Cardiovascular Complications of Non-Steroidal Anti-Inflammatory Drugs.
E. Fosslien (2005)
Ann. Clin. Lab. Sci. 35, 347-385
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The Promise of Prostaglandins: Have They Fulfilled Their Potential as Therapeutic Targets for the Delay of Preterm Birth?.
D. M. Olson (2005)
Reproductive Sciences 12, 466-478
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Cyclooxygenase Inhibitor Ketorolac or Mast Cell Stabilizers: Immunologic Challenges in Cancer Therapy.
M. Khatami and J. Mulshine (2005)
Clin. Cancer Res. 11, 1350-1352
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Resolution for Sepsis?.
D. W. Gilroy and P. Vallance (2005)
Circulation 111, 2-4
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