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Science 3 September 2004:
Vol. 305. no. 5689, pp. 1409 - 1410
DOI: 10.1126/science.1103076
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Perspectives

MOLECULAR BIOLOGY:
Argonaute Journeys into the Heart of RISC

Erik J. Sontheimer and Richard W. Carthew

Identifying the "slicer" component of the RNA-induced silencing complex (RISC) complex has been a major goal of those interested in the RNA interference pathway of gene silencing. In their Perspective, Sontheimer and Carthew discuss a pair of recent studies (Liu et al., Song et al.) that identify the protein Argonaute2 as the slicer element of RISC that cleaves target messenger RNAs.

The authors are in the Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA. E-mail: erik{at}northwestern.edu; r-carthew{at}northwestern.edu

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