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Science 13 August 2004:
Vol. 305. no. 5686, pp. 951 - 953
DOI: 10.1126/science.1102496
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Perspectives

NEUROSCIENCE:
Addicted Rats

Terry E. Robinson

What accounts for the transition from drug use to drug addiction, and why are some individuals more susceptible to this transition than others? Answers to these questions are crucial for understanding the addiction of some individuals to drugs of abuse, but they have been difficult to address because the available animal models are insufficiently realistic. In a Perspective, Robinson discusses complementary studies (Deroche-Gamonet et al.; Vanderschuren and Everitt) in which a realistic rat model has been developed that should help to unravel the psychology and neurobiology of human addiction.

The author is in the Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA. E-mail: ter{at}umich.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Extended Access to Cocaine Self-Administration Enhances Drug-Primed Reinstatement but Not Behavioral Sensitization.
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Withdrawal from cocaine self-administration produces long-lasting deficits in orbitofrontal-dependent reversal learning in rats.
D. J. Calu, T. A. Stalnaker, T. M. Franz, T. Singh, Y. Shaham, and G. Schoenbaum (2007)
Learn. Mem. 14, 325-328
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