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Science 9 July 2004:
Vol. 305. no. 5681, pp. 185 - 187
DOI: 10.1126/science.1100890
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Perspectives

IMMUNOLOGY:
Tracing an Orphan's Genealogy

Delphine Guy-Grand and Pierre Vassalli

Immunologists have long thought that certain populations of intraepithelial T lymphocytes (IELs) are born and raised in the gut mucosa. A new twist on the origin of IELs is provided by Guy-Grand and Vassalli in their Perspective, which discusses new work (Eberl and Littman) identifying the thymus as the birthplace of IELs.

D. Guy-Grand is at Unité de Recherche et d'Expertise Antivirale, INSERM U277, Institut Pasteur, 75724 Paris Cedex 15, France. E-mail: guygrand{at}pasteur.fr P. Vassalli is in the Département de Pathologie, Centre Médical Universitaire, CH-1211 Genève, Switzerland. E-mail: pierre.vassalli{at}medecine.unige.ch

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Science. ISSN 0036-8075 (print), 1095-9203 (online)